Terrance G Johns Selected Research

monoclonal antibody 806

10/2010	MAb 806 enhances the efficacy of ionizing radiation in glioma xenografts expressing the de2-7 epidermal growth factor receptor.
9/2009	Targeting a unique EGFR epitope with monoclonal antibody 806 activates NF-kappaB and initiates tumour vascular normalization.
9/2009	Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients.
12/2007	Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody.
3/2007	A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors.
2/2007	The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers. Implications for combination therapy with monoclonal antibody 806.
9/2005	Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity.
5/2005	The antitumor monoclonal antibody 806 recognizes a high-mannose form of the EGF receptor that reaches the cell surface when cells over-express the receptor.
7/2004	Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor.
12/2003	Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478.

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Terrance G Johns Research Topics

Disease

40	Neoplasms (Cancer) 03/2020 - 03/2002
19	Glioblastoma (Glioblastoma Multiforme) 03/2020 - 05/2009
16	Glioma (Gliomas) 12/2019 - 03/2002
6	Carcinogenesis 01/2019 - 02/2012
4	Ectopic Pregnancy 07/2018 - 01/2013
3	Brain Neoplasms (Brain Tumor) 07/2018 - 01/2018
2	Oncogene Addiction 01/2016 - 05/2009
2	Lymphoma (Lymphomas) 11/2015 - 05/2013
2	Neuroblastoma 11/2015 - 05/2013
2	Colorectal Neoplasms (Colorectal Cancer) 01/2014 - 05/2012
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/2013 - 06/2009
2	Melanoma (Melanoma, Malignant) 10/2012 - 02/2005
1	Sarcoma (Soft Tissue Sarcoma) 01/2020
1	Hepatocellular Carcinoma (Hepatoma) 08/2018
1	Medulloblastoma 01/2018
1	Myxoid Liposarcoma 01/2016
1	Pre-Eclampsia (Preeclampsia) 12/2015
1	Tics (Tic) 03/2015
1	Necrosis 01/2014
1	Diarrhea 10/2013
1	Fetal Resorption 10/2013
1	Exanthema (Rash) 10/2013
1	Neoplasm Metastasis (Metastasis) 10/2013
1	Ovarian Neoplasms (Ovarian Cancer) 10/2012
1	Colonic Neoplasms (Colon Cancer) 05/2012

Drug/Important Bio-Agent (IBA)

30	ErbB Receptors (EGF Receptor)IBA 01/2019 - 08/2003
16	epidermal growth factor receptor VIIIIBA 01/2019 - 03/2002
12	AntibodiesIBA 01/2019 - 03/2002
12	monoclonal antibody 806IBA 10/2010 - 03/2002
11	Monoclonal AntibodiesIBA 01/2014 - 03/2002
7	Proteins (Proteins, Gene)FDA Link 01/2020 - 10/2010
6	Tyrosine Kinase InhibitorsIBA 10/2013 - 10/2005
5	Pharmaceutical PreparationsIBA 03/2020 - 05/2013
5	LigandsIBA 01/2016 - 08/2004
4	Phosphotransferases (Kinase)IBA 01/2018 - 05/2009
3	TubulinIBA 12/2019 - 12/2015
3	Methotrexate (Mexate)FDA LinkGeneric 07/2018 - 01/2013
3	Gefitinib (Iressa)FDA Link 07/2018 - 01/2013
3	rilotumumabIBA 01/2016 - 05/2009
3	Tyrosine (L-Tyrosine)FDA Link 12/2015 - 06/2009
3	AntigensIBA 01/2014 - 08/2003
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 04/2007 - 12/2003
2	Panitumumab (Vectibix)FDA Link 01/2019 - 05/2009
2	Immunotoxins (Immunotoxin)IBA 09/2017 - 12/2007
2	tyrosine receptor (receptor, tyrosine)IBA 09/2013 - 05/2009
2	src-Family KinasesIBA 02/2012 - 09/2009
2	RTKI cpdIBA 02/2007 - 12/2003
1	Protein Kinases (Protein Kinase)IBA 03/2020
1	salinomycinIBA 01/2020
1	IonophoresIBA 01/2020
1	Pemetrexed (MTA)FDA Link 12/2019
1	DNA (Deoxyribonucleic Acid)IBA 12/2019
1	Carboplatin (JM8)FDA LinkGeneric 12/2019
1	Biomarkers (Surrogate Marker)IBA 12/2019
1	Dystroglycans (Dystroglycan)IBA 12/2019
1	Bevacizumab (Avastin)FDA Link 12/2019
1	Neutralizing AntibodiesIBA 08/2018
1	Insulin-Like Growth Factor II (Somatomedin A)IBA 08/2018
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 07/2018
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2018
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2018
1	dacomitinibIBA 01/2018
1	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 01/2018
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	TensinsIBA 01/2018
1	SO1861IBA 09/2017
1	Gelonium multiflorum GEL proteinIBA 09/2017
1	monomethyl auristatin EIBA 09/2017
1	GlycosidesIBA 09/2017
1	TriterpenesIBA 09/2017
1	Calcitonin Receptors (Calcitonin Receptor)IBA 09/2017
1	Immunoconjugates (Immunoconjugate)IBA 09/2017
1	Dyrk KinasesIBA 01/2017
1	Eukaryotic Initiation Factor-4EIBA 01/2016
1	Oncogene Proteins (Oncogene Protein)IBA 01/2016
1	Axitinib (AG 013736)IBA 01/2016
1	Tubulin ModulatorsIBA 12/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2015
1	Protein Isoforms (Isoforms)IBA 12/2015
1	Laminin (Merosin)IBA 03/2015
1	MicroRNAs (MicroRNA)IBA 02/2014
1	Mitochondrial DNA (mtDNA)IBA 01/2014
1	InterferonsIBA 10/2013
1	14-3-3 Proteins (14-3-3 Protein)IBA 10/2013
1	Rituximab (Mabthera)FDA Link 05/2013
1	CamptothecinIBA 05/2013
1	SiliconIBA 05/2013
1	tetraethylpyrazine (TEP)IBA 01/2013
1	Cetuximab (Erbitux)FDA Link 05/2012
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 05/2012
1	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 02/2012
1	Small Interfering RNA (siRNA)IBA 02/2012
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 09/2011
1	Mannose (D-Mannose)IBA 09/2011
1	Glucose (Dextrose)FDA LinkGeneric 09/2011

Therapy/Procedure

17	Therapeutics 01/2020 - 03/2002
3	Drug Therapy (Chemotherapy) 01/2018 - 06/2010
2	Radiotherapy 01/2020 - 06/2010
1	Transplantation 01/2014
1	Infusion Pumps (Infusion Pump) 09/2011